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VALPROIC ACID

Common Tradename
DEPAKENE
Class
anticonvulsant
Dosage, Adult (usual)
epilepsy initial 10-15mg/kg daily (divided doses), MAX 60mg/kg/day
mania 750mg DAILY in divided doses
migraine prophylaxis 250 mg PO BID up to 1000mg/day
Dosage, Pediatric, (usual)
epilepsy 10-15mg/kg/day (divided doses), MAX 60mg/kg/day
Dose Adjustments:
liver disease
geriatircs
Administration
may take with food to avoid GI upset, swallow capsule whole , do NOT chew
How Supplied
250 MG GELATIN CAPSULE
250 MG/5 ML SYRUP
Indications
epilepsy
mania
migraine prophylaxis
Contraindications
hypersensitivity to valproic acid
pregnancy
hepatic disease
Adverse Effects
thrombocytopenia
sedation, dizziness, headache, asthenia
tremor
weight gain
hepatotoxicity, pancreatitis
N/V, diarrhea, abdominal pain
Drug Interactions
acyclovir
amitriptyline
aspirin
betamipron
carbamazepine
cholestyramine
clarithromycin
clomipramine
dehydroepiandrosterone
erythromycin
evening primrose oil
felbamate
fosphenytoin
ginkgo
isoniazid
lamotrigine
lorazepam
mefloquine
nimodipine
panipenem
phenobarbital
phenytoin
primidone
rifampin
topiramate
zidovudine
Pregnancy Category
D
Breast Feeding
safe
Notes
for epilepsy, usual plasma therapeutic levels 50-100mcg/mL
for acute mania, usual plasma therapeutic levels 50-125mcg/mL

REFERENCE: MICROMEDEX(R) Healthcare Series Vol. 111 expires 3/2002

DESIGNED BY HASHIM TAYEB (Bsc PHARM)