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THEOPHYLLINE

Common Tradenames
ELIXOPHYLLIN
SLO-BID
THEO-DUR
Class
bronchodilator, xanthine
Dosage, Adult (usual)
PO 300-600mg/DAY (divide Q6-8H)
IV bolus 4.6mg/kg, then 0.4-0.7mg/kg/hr continuous infusion
Dosage, Pediatric, (usual)
asthma 12-20mg/kg/DAY (divided Q4-6H)
neonatal apnea 5mg/kg load, then 1-1.5mg/kg Q12H
Dose Adjustments:
geriatrics
liver disease
How Supplied
100 MG, 200 MG, 300 MG CAPSULE
80 MG/15 ML ELIXIR
200 MG, 300 MG, 450 MG TER
Indications
asthma
chronic obstructive pulmonary disease
neonatal apnea
Contraindications
hypersensitivity to ethylenediamine or theophylline
Adverse Effects
tachycardia
N/V
tremor
Drug Interactions
adenosine
allopurinol
aminoglutethimide
benzodiazepines
butalbital
carbamazepine
cimetidine
ciprofloxacin
clinafloxacin
diltiazem
dipyridamole
disulfiram
enoxacin
ephedrine
erythromycin
ethinyl estradiol
etintidine
fluvoxamine
fosphenytoin
grepafloxacin
halothane
idrocilamide
imipenem

 

interferon alfa-2a
ipriflavone
isoproterenol
josamycin
ketamine
lithium
mestranol
mexiletine
moricizine
nilutamide
norethindrone
norfloxacin
norgestrel
pancuronium
paroxetine
pefloxacin
pentobarbital
pentoxifylline
phenobarbital
phenytoin
pipemidic acid

 

piperine
primidone
propafenone
propranolol
prulifloxacin
rifampin
ritonavir
ropivacaine
secobarbital
st john's wort
sulfinpyrazone
tacrine
tacrolimus
thiabendazole
ticlopidine
troleandomycin
verapamil
viloxazine
zafirlukast
zileuton

 

Pregnancy Category
C
Breast Feeding
safe
Notes
desired serum conc 10-15mcg/ml

REFERENCE: MICROMEDEX(R) Healthcare Series Vol. 111 expires 3/2002

DESIGNED BY HASHIM TAYEB (Bsc PHARM)