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PHENYTOIN

Common Tradenames 
DILANTIN
PHENYTOIN SODIUM
Class
anticonvulsant
Dosage, Adult (usual)
initial 100mg PO TID, then 300mg QD may be considered based on tolerance
status epilepticus IV 10-15mg/kg followed by maintenance doses of 100mg PO,IV Q6-8H
seizure disorders IV l300-400mg/day divide QD-BID
Dosage, Pediatric, (usual)
neonates 15-20mg/kg /day PO (divide QD-BID)
seizure disorders neonates loading 15-20mg/kg IV, maintenance 4-6mg/kg/day IV divide QD-BID)
seizure disorders infants, children loading 10-15mg/kg IV, maintenance 4-7mg/kg/day IV divide QD-BID
seizure disorders infants, children 4-7mg/kg/day PO divide QD-BID
Dose Adjustments:
geriatrics
renal impairment
hepatic disease
Administration
MAX IV adult rate 50 mg/min, MAX neonates 1-3mg/kg/min; if dilution necessary dilute with NS to a concentration of 1-10mg/mL
How Supplied
100 MG CAPSULE
30 MG EXTENDED-RELEASE CAPSULE
50 MG/ML SOLUTION FOR INJECTION
Indications
epilepsy/seizures
Contraindications
hypersensitivity to phenytoin or hydantoin products
Adverse Effects
nystagmus
ataxia
lethargy
blood dyscrasias
cardiovascular toxicity
Drug Interactions
acenocoumarol
acetaminophen
acetazolamide
acetyldigoxin
acyclovir
amiodarone
amitriptyline
amoxapine
amprenavir
anisindione
apazone
atorvastatin
beclamide
betamethasone
bleomycin
bromfenac
busulfan
capecitabine
carbamazepine
carboplatin
carmustine
caspofungin
chloramphenicol
chlordiazepoxide
chlorpheniramine
cimetidine
ciprofloxacin
cisatracurium
cisplatin
clarithromycin
clobazam
clofazimine
clomipramine
clozapine
cortisone
cyclosporine
deflazacort
delavirdine
desipramine
dexamethasone
diazepam
diazoxide
dicumarol
digitoxin
diltiazem
disopyramide
disulfiram
dopamine
dothiepin
doxepin
doxorubicin
doxorubicin hydrochloride liposome
doxycycline
ethinyl estradiol
ethosuximide
evening primrose oil
felbamate
fluconazole
fludrocortisone
fluoxetine
fluvoxamine
folic acid
ginkgo
hydrocortisone
ibuprofen
imipramine
indinavir
isoniazid
itraconazole
lamotrigine
levodopa
levomethadyl
levonorgestrel
levothyroxine
lidocaine
lofepramine
mebendazole
meperidine
mestranol
methotrexate
methoxsalen
methsuximide
methylprednisolone
metocurine
metronidazole
mexiletine
miconazole
midazolam
nafimidone
nelfinavir
nifedipine
nilutamide
nisoldipine
norethindrone
norgestrel
nortriptyline
omeprazole
oxcarbazepine
paclitaxel
pancuronium
paroxetine
phenprocoumon
phensuximide
phenylbutazone
pipecuronium
piperine
praziquantel
prednisolone
prednisone
progabide
protriptyline
quetiapine
quinidine
remacemide
rifampin
sabeluzole
saquinavir
sertraline
shankhapulshpi
simvastatin
sulfadiazine
sulfamethizole
sulfaphenazole
sulthiame
tacrolimus
tenidap
teniposide
theophylline
tiagabine
ticlopidine
ticrynafen
tirilazad
tizanidine
tolbutamide
topiramate
triamcinolone
trimethoprim
trimipramine
tubocurarine
valproic acid
vecuronium
verapamil
vigabatrin
viloxazine
vinblastine
warfarin
zotepine
Pregnancy Category
D
Breast Feeding
safe
Notes
avoid D5W as IV diluent

REFERENCE: MICROMEDEX(R) Healthcare Series Vol. 111 expires 3/2002

DESIGNED BY HASHIM TAYEB (Bsc PHARM)