 |
Common Tradenames
 |
LUMINAL |
|
SK-PHENOBARBITAL |
|
|
Class
|
barbiturate |
|
|
Dosage, Adult (usual)
|
sedation 30-120mg DAILY PO (divided BID-TID) |
|
epilepsy 60-200mg DAILY PO (divided BID-TID) |
|
hypnotic 100-200 mg PO |
|
|
Dosage, Pediatric, (usual)
|
anticonvulsant neonates-2-5mg/kg/24h divide QD-BID |
|
anticonvulsant infants 5-8mg/kg/24h divide QD-BID |
|
anticonvulsant children 3-5mg/kg/day divide QD-BID |
|
|
Dose Adjustments:
|
renal impairment |
|
liver disease |
|
geriatrics |
|
|
Administration
|
Dilute in IV fluids, infuse slowly by IV push at a rate not to exceed 1mg/kg/minute; IM or SC-give
undiluted injection |
|
|
How Supplied
|
130 MG/ML SOLUTION FOR INJECTION |
|
15 MG TABLET |
|
|
Indications
|
sedative for relief of anxiety, tension |
|
epilepsy |
|
hypnotic for insomnia |
|
|
Contraindications
|
hypersensitivity to phenobarbital products |
|
porphyria |
|
marked impairment of liver function |
|
respiratory disease (dyspnea or obstruction) |
|
|
Adverse Effects
|
hypotension |
|
drowsiness |
|
ataxia |
|
respiratory depression |
|
dyskinesias |
|
|
Drug Interactions
|
|
|
acenocoumarol |
|
alprenolol |
|
amprenavir |
|
anisindione |
|
betamethasone |
|
capsaicin |
|
carbamazepine |
|
chloramphenicol |
|
chlorpromazine |
|
cholestyramine |
|
clozapine |
|
cortisone |
|
cyclosporine |
|
deflazacort |
|
delavirdine |
|
dexamethasone |
|
dicumarol |
|
digitoxin |
|
disopyramide |
|
doxycycline |
|
ethinyl
estradiol |
|
ethosuximide |
|
|
eucalyptus |
|
evening
primrose oil |
|
felodipine |
|
fludrocortisone |
|
ginkgo |
|
griseofulvin |
|
guanfacine |
|
hydrocortisone |
|
indinavir |
|
itraconazole |
|
kava |
|
lamotrigine |
|
leucovorin |
|
levomethadyl |
|
levonorgestrel |
|
mestranol |
|
methoxyflurane |
|
methylprednisolone |
|
metoprolol |
|
nelfinavir |
|
nimodipine |
|
norethindrone |
|
|
norgestrel |
|
paramethasone |
|
phenindione |
|
phenprocoumon |
|
phenylbutazone |
|
prednisolone |
|
prednisone |
|
promethazine |
|
propranolol |
|
quinidine |
|
saquinavir |
|
sevoflurane |
|
tacrolimus |
|
teniposide |
|
theophylline |
|
thioridazine |
|
tiagabine |
|
triamcinolone |
|
valerian |
|
valproic
acid |
|
verapamil |
|
warfarin |
|
zotepine |
|
|
|
Pregnancy Category
|
D |
|
|
Breast Feeding
|
unsafe |
|
