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PHENOBARBITAL SODIUM

Common Tradenames 
LUMINAL
SK-PHENOBARBITAL
Class
barbiturate
Dosage, Adult (usual)
sedation 30-120mg DAILY PO (divided BID-TID)
epilepsy 60-200mg DAILY PO (divided BID-TID)
hypnotic 100-200 mg PO
Dosage, Pediatric, (usual)
anticonvulsant neonates-2-5mg/kg/24h divide QD-BID
anticonvulsant infants 5-8mg/kg/24h divide QD-BID
anticonvulsant children 3-5mg/kg/day divide QD-BID
Dose Adjustments:
renal impairment
liver disease
geriatrics
Administration
Dilute in IV fluids, infuse slowly by IV push at a rate not to exceed 1mg/kg/minute; IM or SC-give undiluted injection
How Supplied
130 MG/ML SOLUTION FOR INJECTION
15 MG TABLET
Indications
sedative for relief of anxiety, tension
epilepsy
hypnotic for insomnia
Contraindications
hypersensitivity to phenobarbital products
porphyria
marked impairment of liver function
respiratory disease (dyspnea or obstruction)
Adverse Effects
hypotension
drowsiness
ataxia
respiratory depression
dyskinesias
Drug Interactions
acenocoumarol
alprenolol
amprenavir
anisindione
betamethasone
capsaicin
carbamazepine
chloramphenicol
chlorpromazine
cholestyramine
clozapine
cortisone
cyclosporine
deflazacort
delavirdine
dexamethasone
dicumarol
digitoxin
disopyramide
doxycycline
ethinyl estradiol
ethosuximide
eucalyptus
evening primrose oil
felodipine
fludrocortisone
ginkgo
griseofulvin
guanfacine
hydrocortisone
indinavir
itraconazole
kava
lamotrigine
leucovorin
levomethadyl
levonorgestrel
mestranol
methoxyflurane
methylprednisolone
metoprolol
nelfinavir
nimodipine
norethindrone
norgestrel
paramethasone
phenindione
phenprocoumon
phenylbutazone
prednisolone
prednisone
promethazine
propranolol
quinidine
saquinavir
sevoflurane
tacrolimus
teniposide
theophylline
thioridazine
tiagabine
triamcinolone
valerian
valproic acid
verapamil
warfarin
zotepine
Pregnancy Category
D
Breast Feeding
unsafe

REFERENCE: MICROMEDEX(R) Healthcare Series Vol. 111 expires 3/2002

DESIGNED BY HASHIM TAYEB (Bsc PHARM)