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CHLORAMPHENICOL

Common Tradename
CHLOROMYCETIN
Class
antibiotic
Dosage, Adult (usual)
50-100mg/kg/day IV (divide Q6H)
Dosage, Pediatric, (usual)
50-100mg/kg/day IV(divide Q6H)
Dose Adjustments:
renal impairment
liver disease
Administration
adjust dose based on serum levels
How Supplied
1 G INJECTION
1 GRAM/10 ML POWDER FOR INJECTION
Indications
Bacteroides, H influenzae
N meningitidis, Salmonella
rickettsial infections
lymphogranuloma-psittacosis group
gram-negative bacteremia
Contraindications
hypersensitivity to chloramphenicol products
Adverse Effects
N/V
irreversible aplastic anemia
rash
myelosuppression
gray baby syndrome (children)
Drug Interactions
ceftazidime
chlorpropamide
cyclophosphamide
cyclosporine
dicumarol
entacapone
fosphenytoin
glimepiride
phenobarbital
phenytoin
rifampin
tacrolimus
tetanus toxoid
tolbutamide
typhoid vaccine
warfarin
Pregnancy Category
C
Breast Feeding
unsafe
Notes
not first-line agent/no prophy role

REFERENCE: MICROMEDEX(R) Healthcare Series Vol. 111 expires 3/2002

DESIGNED BY HASHIM TAYEB (Bsc PHARM)